Debio (1143-201)

A phase I/II randomized study to determine the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of Debio 1143 combined with concurrent chemo-radiation therapy in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).
Coordinator : Prof. BOURHIS
Start date : 2016
Number of patients : 96

Access detailed information on the trial in the private section

 

TPExtreme (GORTEC 2014-01)

Phase III trial comparing Extreme versus TPEx as a first-line treatment in recurrent and/or metastatic HNSCC.
Coordinator : Prof. Guigay
Start date : 2015
Expected number of patients : 416

Access the Clinical Trials link

Access detailed information on the trial in the private section

 

ELAN STUDIES

Study of tailored treatment of patients aged over 70 years with squamous cell carcinoma of the upper aerodigestive tract following geriatric assessment.
Coordinator : Dr GUIGAY - Dr ORTHOLAN - Dr LE CAER
Start date : 2011
Expected number of patients : 426

Access the ELAN-RT Clinical Trials link

Access the ELAN-FIT Clinical Trials link

Access detailed information on the trial in the private section

 

TAPIS (GORTEC 2013-01)

Phase I study evaluating the combination Afatinib (BIBW2992) with Docetaxel and Cisplatin (TPA) in induction chemotherapy in locally advanced squamous cell carcinoma of the upper aerodigestive tract.
Coordinator: Dr Cupissol
Start date: 2015
Expected number of patients : 23

Access the Clinical Trials link

Access detailed information on the trial in the private section

 

GORTEC 2008-01

Phase II non-randomized re-irradiation study, tumor in place, Bifractionated radiotherapy 1.2 Gy/s 5 ½ weeks 66 Gy with ERBITUX 400 mg/m² D1 then 250 mg/m² weekly + QA
Coordinator : DR MARTIN
Start date : 2008
Number of patients    62

Access the Clinical Trials link

Access detailed information on the trial in the private section

 

GORTEC/GETTEC JANORL2

Randomized, phase II-III trial comparing two re-irradiation protocols after surgery in an irradiated area for carcinoma of the upper aerodigestive tract: Radiotherapy with concomitant 5FU and Hydroxycarbamide (1 week in 2) or Bifractionated radiotherapy with concomitant cetuximab (continuous)
Coordinator : Dr JANOT 
Start date: 2010
Number of patients    328

Access the Clinical Trials link

Access detailed information on the trial in the private section

 

GORTEC 2010-02

Randomized, double-blind, placebo-controlled phase III trial to evaluate the efficacy of BIBW 2992 (afatinib) in maintenance therapy after postoperative radio-chemotherapy in squamous cell carcinoma of the upper aerodigestive tract
Coordinator : DR RACADOT - DR POMMIER
Start date : 2011
Number of patients    315

Access the Clinical Trials link

Access detailed information on the trial in the private section