Publications réalisées par le Gortec

Ces publications sont classées par ordre chronologique décroissant.

GORTEC 2007-01

Randomized Trial of Concomitant Chemotherapy in Patients With Locally Advanced HNSCC Treated by Radiotherapy-erbitux (2007-01)
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Essai randomisé multicentrique de phase III évaluant l'apport d'une chimiothérapie concomitante chez les patients traités par radiothérapie - Erbitux pour un carcinome localement évolué des VADS <= N2a.
Coordinateur : Pr BOURHIS
Date de début : 2008
Nb Patients    406

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GORTEC 2007-02

Chemoradiotherapy HNSCC, Randomized Study, Docetaxel,Cisplatin, 5FU,Erbitux. (2007/02)

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Etude de phase III randomisée, multicentrique comparant une chimiothérapie d'induction par TPF suivie d'une association radiothérapie Erbitux® versus une radiochimiothérapie concomitante chez des patients présentant un carcinome épidermoïde des VADS localement évolué inopérable >=N2b
Coordinateur : Dr GEOFFROIS
Date de début : 2009
Nb Patients    360

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J Clin Oncol. 2013 Mar

Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study.

Lefebvre JL1, Pointreau Y, Rolland F, Alfonsi M, Baudoux A, Sire C, de Raucourt D, Malard O, Degardin M, Tuchais C, Blot E, Rives M, Reyt E, Tourani JM, Geoffrois L, Peyrade F, Guichard F, Chevalier D, Babin E, Lang P, Janot F, Calais G, Garaud P, Bardet E.

[ Voir la publication complète ]

Radiat Oncol. 2013 Feb

Phase I trial of oral etoposide in combination with radiotherapy in head and neck squamous cell carcinoma - GORTEC 2004-02

Tao Y, Bardet E, Rosine D, Rolland F, Bompas E, Daly-Schveitzer N, Lusinchi A, Bourhis J.

[ Voir la publication complète ]

Lancet Oncol. 2012 Apr

Absent benefit of accelerated concomitant chemoradiotherapy (GORTEC 99-02)  

Bourhis J, Tao YG, Blanchard P, Sire C, Aupérin A .

[ Voir la publication complète ]

The Lancet Oncology. 2012 Feb

Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial

Prof Jean Bourhis, Christian Sire, Pierre Graff, Prof Vincent Grégoire,Prof Philippe Maingon,Prof Gilles Calais, Bernard Gery, Laurent Martin, Marc Alfonsi, Patrick Desprez, Thierry Pignon, Etienne Bardet, Michel Rives, Lionel Geoffrois, Prof Nicolas Daly-Schveitzer, Sok Sen, Claude Tuchais, Olivier Dupuis, Stéphane Guerif, Michel Lapeyre, Véronique Favrel, Prof Marc Hamoir, Antoine Lusinchi, Stéphane Temam, Antonella Pinna, BScYun Gan Tao, Pierre Blanchard, Anne Aupérin

[ Voir la publication complète (The lancet) ]

[ Voir la publication complète (pubmed)]

Radiother Oncol. 2011 Jul

Accelerated radiotherapy and concomitant high dose chemotherapy in non resectable stage IV locally advanced HNSCC: results of a GORTEC randomized trial.

Bourhis J, Lapeyre M, Tortochaux J, Lusinchi A, Etessami A, Ducourtieux M, Geoffrois L, Domenge C, Verrelle P, Wibault P, Janot F, Temam S, Blanchard P, Tao YG, Auperin A. Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France

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[ Voir la publication complète ]

Radiother Oncol. 2011 Jul

Randomized phase III trial (GORTEC 98-03) comparing re-irradiation plus chemotherapy versus methotrexate in patients with recurrent or a second primary head and neck squamous cell carcinoma, treated with a palliative intent.

Tortochaux J, Tao Y, Tournay E, Lapeyre M, Lesaunier F, Bardet E, Janot F, Lusinchi A, Benhamou E, Bontemps P, Maingon P, Calais G, Daly-Schveitzer N, Verrelle P, Bourhis J.

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Radiother Oncol. 2011 Jan

A phase I trial combining oral cisplatin (CP Ethypharm) with radiotherapy in patients with locally advanced head and neck squamous cell carcinoma.

Tao Y, Rezaï K, Brain E, Etessami A, Lusinchi A, Temam S, Urien S, Van ML, Vauzelle-Kervroedan F, Lokiec F, Daly-Schveitzer N, Bourhis J.

[ Voir la publication complète ]

J Clin Oncol. 2010 Nov 29

Subcutaneous Compared With Intravenous Administration of Amifostine in Patients With Head and Neck Cancer Receiving Radiotherapy: Final Results of the GORTEC 2000-02 Phase III Randomized Trial.

Bardet E, Martin L, Calais G, Alfonsi M, Feham NE, Tuchais C, Boisselier P, Dessard-Diana B, Seng SH, Garaud P, Aupérin A, Bourhis J.

 [ Voir la publication complète ]

J Clin Oncol. - 2010 Jan 1

Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01.

Machiels JP, Henry S, Zanetta S, Kaminsky MC, Michoux N, Rommel D, Schmitz S, Bompas E, Dillies AF, Faivre S, Moxhon A, Duprez T, Guigay J.
Medical Oncology Unit, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc

[ Voir la publication complète ]

Int J Radiat Oncol Biol Phys. - 2009 Apr 20

TPF : a rational choice for larynx preservation ?

Calais G.

[ Voir la publication complète ]

Concomitant Chemoradiotherapy Using Carboplatin, Tegafur-Uracil and Leucovorin for Stage III and IV Head-and-Neck Cancer: Results of GORTEC Phase II Study.

Fesneau M, Pointreau Y, Chapet S, Martin L, Pommier P, Alfonsi M, Laguerre B, Feham N, Berger C, Garaud P, Calais G.
Department of Radiation Oncology, Henry Kaplan Center, Tours, France.

Larynx preservation clinical trial design: key issues and recommendations--a consensus panel summary.
Ang K, Bardet E, Barry B, Bernier J, Bourhis J, Budach V, Calais G, Conley B, Forastiere A, Knecht R, Langendijk J, Lefebvre JL, Leemans R, Licitra L, Posner M, de Raucourt D, Rolland F, Temam S, Vermorken JB, Vokes E, Weber RS, Wolf G.
Département de Cancérologie Cervico-Faciale, Centre Oscar Lambret, Lille, France

J Natl Cancer Inst. 2009 Apr 1

Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation.

Pointreau Y, Garaud P, Chapet S, Sire C, Tuchais C, Tortochaux J, Faivre S, Guerrif S, Alfonsi M, Calais G.

 J Clin Oncol - 2008 Dec 1

Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma. 
Janot F, de Raucourt D, Benhamou E, Ferron C, Dolivet G, Bensadoun RJ, Hamoir M, Géry B, Julieron M, Castaing M, Bardet E, Grégoire V, Bourhis J. 
Institut Gustave-Roussy, 39 rue Camille Desmoulins, Villejuif, France

Rev Prat. - 2006 Oct 15

J Clin Oncol. - 2006 Jun 20

Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: a GORTEC trial 
Bourhis J, Lapeyre M, Tortochaux J, Rives M, Aghili M, Bourdin S, Lesaunier F, Benassi T, Lemanski C, Geoffrois L, Lusinchi A, Verrelle P, Bardet E, Julieron M, Wibault P, Luboinski M, Benhamou E. 
Institut Gustave Roussy, Radiation Oncology, Head and Neck Statistics Department, Villejuif, France

Int J Radiat Oncol Biol Phys. - 2006 Mar 15

French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: Results at 2 years (FNCLCC-GORTEC). 
Bensadoun RJ, Bénézery K, Dassonville O, Magné N, Poissonnet G, Ramaïoli A, Lemanski C, Bourdin S, Tortochaux J, Peyrade F, Marcy PY, Chamorey E, Vallicioni J, Seng H, Alzieu C, Géry B, Chauvel P, Schneider M, Santini J, Demard F, Calais G.
Department of Radiation Oncology, Centre Antoine Lacassagne, Nice, France

Cancer Radiother. - 2005 Jun

Propositions for the selection and the delineation of peritumoral microscopic disease volumes in oral cavity and oropharyngeal cancers (lymph nodes excluded)
Bensadoun RJ, Bénézery K, Dassonville O, Magné N, Poissonnet G, Ramaïoli A, Lemanski C, Bourdin S, Tortochaux J, Peyrade F, Marcy PY, Chamorey E, Vallicioni J, Seng H, Alzieu C, Géry B, Chauvel P, Schneider M, Santini J, Demard F, Calais G., GORTEC 
Département de radiothérapie, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-Lès-Nancy, France

Cancer Radiother. - 2005 Feb

Larynx preservation, state of the art
Lefebvre JL, Calais G. 
Département de cancérologie cervicofaciale, centre Oscar-Lambret, 3, rue Combemale, 59020 Lille cedex, France.

Cancer Radiother. 2005 Jun;9(4):261-70. Epub 2005 Apr 25.

Propositions for the selection and the delineation of peritumoral microscopic disease volumes in oral cavity and oropharyngeal cancers (lymph nodes excluded)
Lapeyre M, Henrot P, Alfonsi M, Bardet E, Bensadoun RJ, Dolivet G, Favrel V, Gallocher O, Giraud P, Graff P, Guerif S, Lagarde P, Lartigau E, Marchesi V, Pommier P, Rives M, Tortochaux J, Toussaint B, Verrelle P, Bourhis J, Calais G; Groupe Oncologie Radiothérapie Tête et Cou.
Département de radiothérapie, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-Lès-Nancy, France. m.lapeyre[@]nancy.fnclcc.fr

Semin Oncol. - 2004 Dec

Concomitant radiochemotherapy or accelerated radiotherapy: analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC). 
Bourhis J, Calais G, Lapeyre M, Tortochaux J, Alfonsi M, Sire C, Bardet E, Rives M, Bergerot P, Rhein B, Desprez B; French Head and Neck Cancer Group (GORTEC). 
Department of Radiation-Oncology, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94805 Villejuif, France.

Curr Opin Oncol. - 2004 May

Altered fractionated radiotherapy in the management of head and neck carcinomas: advantages and limitations. 
Bourhis J, Etessami A, Wilbault P, Lusinchi A, Calais G, Lapeyre M, Pignon JP. 
Institut Gustave Roussy, Radiation Oncology & Statistic Departments, Villejuif, France.

Bull Cancer. - 2004 Feb

Docetaxel and squamous cell carcinoma of the head and neck
Calais G. 
Clinique d'oncologie et radiothérapie, Hôpital Bretonneau, 2, bd Tonnellé, 37044 Tours.

Int J Radiat Oncol Biol Phys. - 2004 Jan 1

Radiotherapy with concomitant weekly docetaxel for Stages III/IV oropharynx carcinoma. Results of the 98-02 GORTEC Phase II trial. 
Calais G, Bardet E, Sire C, Alfonsi M, Bourhis J, Rhein B, Tortochaux J, Man YT, Auvray H, Garaud P. 
Centre Hospitalier Universitaire, Tours, France

J Clin Oncol. - 2004 Jan 1

Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. 

Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G. 
Clinique d'Oncologie et Radiothérapie, Hôpital Bretonneau, 2 Blvd Tonnelé, 37044 Tours, France

Radiother Oncol - 2003 Dec

FCT-based delineation of lymp node levels and related CTVs in the node-negative neck : DAHANCA, EORTC, GORTEC, NCIC, RTOG concensus guidelines
Grégoire V, Levendag P, Ang KK, Bernier J, Braaksma M, Budach V, Chao C, Coche E, Cooper JS, Cosnard G, Eisbruch A, El-Sayed S, Emami B, Grau C, Hamoir M, Lee N, Maingon P, Muller K, Reychler H.

Radiation Oncology Dept. and Laboratory of Radiobiology, Université Catholique de Louvain, St-Luc University Hospital, B-1200 Brussels, Belgium.

Radiother Oncol - 2003 Dec

FLate toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage orophraynx carcinoma : comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems.

Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P, Calais G.

Clinique d'Oncologie et de Radiothérapie, Centre Hospitalier Universitaire, Tours, France

Semin Oncol. - 2002 Dec

Preliminary data of the GORTEC 2000-02 phase III trial comparing intravenous and subcutaneous administration of amifostine for head and neck tumors treated by external radiotherapy. 
Bardet E, Martin L, Calais G, Tuchais C, Bourhis J, Rhein B, Feham N, Alphonsi M. 
CRLCC Nantes Atlantique, Nantes, France.

Bull Cancer. - 2000 Aug

Stage III and IV cancers of the oropharynx: results of a randomized study of Gortec comparing radiotherapy alone with concomitant chemotherapy
Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P, Bertrand P. 
Clinique d'oncologie et radiothérapie, Hôpital Bretonneau, Tours

J Natl Cancer Inst. - 1999 Dec 15

Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. 
Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P, Bertrand P. 
G. Calais, Centre Hospitalier Universitaire Tours, France